Moon H W, Norman J O, Lambert G
Can J Comp Med. 1973 Apr;37(2):157-66.
Pigs were exposed to transmissible gastroenteritis (TGE) virus when three days old or when 21 days old. Diarrhea was earliest in onset, most frequent, most profuse and most prolonged in the youngest group. Pigs exposed when three days old also had a higher case fatality rate than those exposed when 21 days old. The histological response of both groups to exposure was atrophy of villi and hyperplasia of crypts in jejunum and ileum. However, from days three to seven post-exposure, when most fatalities occurred in the younger group, atrophy of villi was both more intensive and extensive in the younger group. Hyperplasia of crypts was also greater and more prolonged in the younger group. Regeneration of atrophic villi was more rapid in jejunum than ileum in both groups. Results were interpreted to indicate two populations, with different rates of regeneration, in the 21-day old group. Based on this interpretation, regeneration of villi was more rapid in one population from the 21-day old group than in the three-day old group. The length of villi and depth of crypts in control pigs varied longitudinally (i.e. from site to site) in the intestine, within each age group. Length of villi and depth of crypts in control pigs also varied with age.
仔猪在3日龄或21日龄时接触传染性胃肠炎（TGE）病毒。腹泻在最年幼的组中发病最早、最频繁、最严重且持续时间最长。3日龄时接触病毒的仔猪的病死率也高于21日龄时接触病毒的仔猪。两组仔猪接触病毒后的组织学反应均为空肠和回肠绒毛萎缩及隐窝增生。然而，在接触病毒后的第3至7天，即最年幼组中出现大多数死亡病例的时期，最年幼组的绒毛萎缩在程度和范围上都更严重。最年幼组的隐窝增生也更显著且持续时间更长。两组中，空肠萎缩绒毛的再生均比回肠更快。结果被解释为表明21日龄组存在两个再生速率不同的群体。基于这一解释，21日龄组中一个群体的绒毛再生比3日龄组更快。在每个年龄组内，对照仔猪的绒毛长度和隐窝深度在肠道内沿纵向（即从一个部位到另一个部位）存在差异。对照仔猪的绒毛长度和隐窝深度也随年龄而变化。
