Puget A, Vergnes H, Gouarderes C
Can J Comp Med. 1974 Jul;38(3):314-20.
The authors made a comparative study of red cell enzyme glycolysis in man and in two species of Lagomorphae, the pika and the rabbit. The activities of the 12 enzymes of Embden-Meyerhoff pathway and of the two dehydrogenases of pentose shunt (glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase) were determined. Phosphoglycerate kinase and pyruvate kinase showed quite similar activities in pika erythrocytes and in erythrocytes from human umbilical cord. The levels of these enzymes differed significantly in the pika and in the rabbit. No differences were noted between pyruvate kinases from the rabbit and the neonatal man. The other activities gave values either identical to those found in the adult man or intermediate between the adult and the neonatal man. In the rabbit the levels of glycolitic enzymes were generally lower than in the pika except for lactate dehydrogenase and glycose-6-phosphate dehydrogenase. Some characteristics of erythrocyte metabolism specific to the pika may account for the differences observed in this species. The influence of red cell age cannot explain the variations observed for no significant reticulocytosis was observed in the circulating blood. The percentages found in the pika and the rabbit were essentially identical at determination.
作者对人类以及两种兔形目动物（鼠兔和兔子）的红细胞糖酵解进行了比较研究。测定了糖酵解途径中12种酶以及磷酸戊糖途径中两种脱氢酶（葡萄糖-6-磷酸脱氢酶和6-磷酸葡萄糖酸脱氢酶）的活性。磷酸甘油酸激酶和丙酮酸激酶在鼠兔红细胞和人脐带血红细胞中的活性非常相似。这些酶的水平在鼠兔和兔子之间存在显著差异。兔子和新生儿的丙酮酸激酶之间未发现差异。其他酶的活性值要么与成年人中的相同，要么介于成年人和新生儿之间。在兔子中，除乳酸脱氢酶和葡萄糖-6-磷酸脱氢酶外，糖酵解酶的水平通常低于鼠兔。鼠兔红细胞代谢的一些特定特征可能解释了在该物种中观察到的差异。红细胞年龄的影响无法解释所观察到的变化，因为在循环血液中未观察到明显的网织红细胞增多。在测定时，鼠兔和兔子中的百分比基本相同。
