• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

正常细胞与病毒转化细胞表面膜结构的差异。

A difference in the architecture of the surface membrane of normal and virally transformed cells.

作者信息

Burger M M

出版信息

Proc Natl Acad Sci U S A. 1969 Mar;62(3):994-1001. doi: 10.1073/pnas.62.3.994.

DOI:10.1073/pnas.62.3.994
PMID:4308100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC223697/
Abstract

Several tissue culture cell lines that were transformed by a tumor virus have been found to react with an agglutinin, while under identical conditions their untransformed parent cell lines did not agglutinate. Since a short treatment of the parent cell line with low concentrations of proteases exposed the same agglutinin receptor sites in a fashion indistinguishable from the transformed cells, it is proposed that both viral and chemical transformation produce changes in the architecture of the membrane, identical to those of the proteases.

摘要

已发现几种被肿瘤病毒转化的组织培养细胞系会与一种凝集素发生反应，而在相同条件下，它们未转化的亲本细胞系却不会凝集。由于用低浓度蛋白酶对亲本细胞系进行短暂处理后，会以与转化细胞难以区分的方式暴露相同的凝集素受体位点，因此有人提出病毒转化和化学转化都会使细胞膜结构产生变化，这与蛋白酶所造成的变化相同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b02/223697/f2b1cc5a8f95/pnas00105-0377-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b02/223697/d1aef04e9ee5/pnas00105-0377-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b02/223697/f2b1cc5a8f95/pnas00105-0377-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b02/223697/d1aef04e9ee5/pnas00105-0377-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b02/223697/f2b1cc5a8f95/pnas00105-0377-b.jpg

相似文献

1
A difference in the architecture of the surface membrane of normal and virally transformed cells.正常细胞与病毒转化细胞表面膜结构的差异。
Proc Natl Acad Sci U S A. 1969 Mar;62(3):994-1001. doi: 10.1073/pnas.62.3.994.
2
Binding of radioactively labelled concanavalin A and wheat germ agglutinin to normal and virus-transformed cells.放射性标记的伴刀豆球蛋白A和麦胚凝集素与正常细胞及病毒转化细胞的结合
Nat New Biol. 1971 Aug 4;232(31):156-60. doi: 10.1038/newbio232156a0.
3
Virus-associated gain and loss of proliferative and neoplastic properties of normal and virus-transformed diploid cell lines.病毒相关的正常和病毒转化的二倍体细胞系增殖及肿瘤特性的获得与丧失
Natl Cancer Inst Monogr. 1968 Dec;29:241-68.
4
Quantitative binding of 125 I-concanavalin A to normal and transformed cells.125I-伴刀豆球蛋白A与正常细胞和转化细胞的定量结合。
J Virol. 1971 Nov;8(5):716-21. doi: 10.1128/JVI.8.5.716-721.1971.
5
[ONCOGENICITY, VIRAL SENSITIVITY AND CYTOGENETIC CHARACTERS OF HAMSTER CELL LINES TRANSFORMED BY THE SV 40 VIRUS].[经SV40病毒转化的仓鼠细胞系的致癌性、病毒敏感性及细胞遗传学特征]
Rev Can Biol. 1964 Sep;23:303-22.
6
Surface changes in transformed cells detected by lectins.通过凝集素检测转化细胞的表面变化。
Fed Proc. 1973 Jan;32(1):91-101.
7
Mitogenic and antimitogenic transforming growth factors secreted by adenovirus 2- and simian virus 40-transformed hamster cells: possible roles in promoting tumorigenesis.腺病毒2型和猿猴病毒40转化的仓鼠细胞分泌的促有丝分裂和抗有丝分裂转化生长因子：在促进肿瘤发生中的可能作用。
Cancer Res. 1987 Aug 1;47(15):4086-92.
8
Ultrastructural comparison between the distribution of concanavalin A and wheat germ agglutinin cell surface receptors of normal and transformed hamster and rat cell lines.正常及转化的仓鼠和大鼠细胞系中伴刀豆球蛋白A和麦胚凝集素细胞表面受体分布的超微结构比较
Cancer Res. 1974 Jan;34(1):230-43.
9
[Characterization of a cell strain derived from a hamster tumor induced with the hybrid PARA-adenovirus 7].
Ann Sclavo. 1971 Sep-Oct;13(5):597-612.
10
Binding of 3 H-concanavalin A by normal and transformed cells.正常细胞和转化细胞对3H-伴刀豆球蛋白A的结合。
Nat New Biol. 1971 Aug 4;232(31):155-6. doi: 10.1038/newbio232155a0.

引用本文的文献

1
Nanoarchitectonics meets cell surface engineering: shape recognition of human cells by halloysite-doped silica cell imprints.纳米结构学与细胞表面工程学的结合：基于埃洛石掺杂二氧化硅细胞印记的人类细胞形状识别
Beilstein J Nanotechnol. 2019 Sep 4;10:1818-1825. doi: 10.3762/bjnano.10.176. eCollection 2019.
2
Histochemical effects of the proteolytic enzyme brinase on ascites tumour cells.组织化学酶法 brinase 对腹水肿瘤细胞的影响。
Ir J Med Sci. 1975 Dec;144(1):312. doi: 10.1007/BF02939031.
3
Identification of Antigenic Glycans from Schistosoma mansoni by Using a Shotgun Egg Glycan Microarray.

本文引用的文献

1
Identification of a tumor-specific determinant on neoplastic cell surfaces.肿瘤细胞表面肿瘤特异性决定簇的鉴定。
Proc Natl Acad Sci U S A. 1967 Feb;57(2):359-66. doi: 10.1073/pnas.57.2.359.
2
UPTAKE OF HYDROCARBON CARCINOGENS BY LYSOSOMES.溶酶体对烃类致癌物的摄取
Nature. 1964 Sep 5;203:1024-7. doi: 10.1038/2031024b0.
3
REACTIONS OF NORMAL AND TUMOR CELL SURFACES TO ENZYMES. I. WHEAT-GERM LIPASE AND ASSOCIATED MUCOPOLYSACCHARIDES.正常细胞与肿瘤细胞表面对酶的反应。I. 小麦胚芽脂肪酶及相关粘多糖
利用鸟枪法虫卵聚糖微阵列鉴定曼氏血吸虫的抗原聚糖
Infect Immun. 2016 Apr 22;84(5):1371-1386. doi: 10.1128/IAI.01349-15. Print 2016 May.
4
Studies on plasma membranes XVII. On the chemical composition of plasma membranes prepared from rat and mouse liver and hepatomas.血浆膜研究 XVII. 大鼠和小鼠肝及肝癌血浆膜的化学成分。
J Membr Biol. 1972 Dec;9(1):83-104. doi: 10.1007/BF01868045.
5
Location of amino acid and carbohydrate transport sites in the surface membrane of normal and transformed mammalian cells.正常和转化哺乳动物细胞表面膜中氨基酸和碳水化合物转运部位的位置。
J Membr Biol. 1971 Sep;6(3):195-209. doi: 10.1007/BF01872277.
6
Changes in the structural organization of the surface membrane in malignant cell transformation.恶性细胞转化中表面膜结构组织的变化。
J Membr Biol. 1971 Sep;6(3):183-94. doi: 10.1007/BF01872276.
7
Different locations of carbohydrate-containing sites in the surface membrane of normal and transformed mammalian cells.正常和转化哺乳动物细胞表面膜中碳水化合物结合位点的不同位置。
J Membr Biol. 1970 Dec;3(1):267-79. doi: 10.1007/BF01868019.
8
Application of microarrays for deciphering the structure and function of the human glycome.微阵列在破译人类糖组结构和功能中的应用。
Mol Cell Proteomics. 2013 Apr;12(4):902-12. doi: 10.1074/mcp.R112.027110. Epub 2013 Feb 14.
9
Hypothetical two-step initiation of experimental carcinogenesis by polycyclic aromatic hydrocarbons and aminoazo dyes.多环芳烃和氨基偶氮染料引发实验性致癌作用的假设性两步启动过程。
Open Biochem J. 2012;6:40-2. doi: 10.2174/1874091X01206010040. Epub 2012 Apr 27.
10
Differences in hydropathic properties of ligand binding at four independent sites in wheat germ agglutinin-oligosaccharide crystal complexes.小麦胚凝集素-寡糖晶体复合物中四个独立位点处配体结合的亲水性性质差异。
Protein Sci. 1996 Aug;5(8):1466-76. doi: 10.1002/pro.5560050803.
Proc Natl Acad Sci U S A. 1963 Oct;50(4):613-9. doi: 10.1073/pnas.50.4.613.
4
The surface properties of cancer cells: a review.癌细胞的表面特性：综述
Cancer Res. 1962 Jun;22:525-48.
5
The inhibition of tumour growth by enzymes in tissue culture.组织培养中酶对肿瘤生长的抑制作用。
Exp Cell Res. 1961 Aug;24:220-7. doi: 10.1016/0014-4827(61)90424-4.
6
Immunologic relationship between blood group substances and a fucose-containing glycolipid of human adenocarcinoma.血型物质与人类腺癌中一种含岩藻糖的糖脂之间的免疫关系。
J Immunol. 1967 Jan;98(1):31-8.
7
Specificity of the agglutinin in extracts of wheat germ.小麦胚芽提取物中凝集素的特异性。
Nature. 1968 Mar 2;217(5131):860-1. doi: 10.1038/217860a0.
8
Altered nucleic acid metabolism in human cell cultures infected with mycoplasma.感染支原体的人类细胞培养物中核酸代谢的改变。
Proc Natl Acad Sci U S A. 1968 Jun;60(2):583-9. doi: 10.1073/pnas.60.2.583.
9
Reactions of normal and leukemic cell surfaces to a wheat germ agglutinin.正常细胞和白血病细胞表面对麦胚凝集素的反应。
Proc Natl Acad Sci U S A. 1965 Aug;54(2):400-2. doi: 10.1073/pnas.54.2.400.
10
Isolation of a receptor complex for a tumor specific agglutinin from the neoplastic cell surface.从肿瘤细胞表面分离肿瘤特异性凝集素的受体复合物。
Nature. 1968 Aug 3;219(5153):499-500. doi: 10.1038/219499a0.