大鼠肝脏各类细胞核中烟酰胺腺嘌呤二核苷酸和聚（腺苷二磷酸核糖）的合成
The synthesis of nicotinamide-adenine dinucleotide and poly (adenosine diphosphate ribose) in various classes of rat liver nuclei.
作者信息
Haines M E, Johnston I R, Mathias A P, Ridge D
出版信息
Biochem J. 1969 Dec;115(5):881-7. doi: 10.1042/bj1150881.
Abstract
- The activities of NMN adenylyltransferase and an enzyme that synthesizes poly (ADP-ribose) from NAD were investigated in the various classes of rat liver nuclei fractionated by zonal centrifugation. 2. The highest specific activities of these two nuclear enzymes occur in different classes of nuclei. In very young and in mature rats it was shown that a correlation exists between DNA synthesis and NMN adenylyltransferase activity, but in rats of intermediate age this correlation is less evident. The highest activities of the enzyme that catalyses formation of poly (ADP-ribose) are in the nuclei involved in the synthesis of RNA. 3. The significance of these results in relation to NAD metabolism is discussed.
摘要
- 采用区带离心法对大鼠肝脏细胞核进行分级分离，研究了烟酰胺单核苷酸腺苷酸转移酶以及一种由烟酰胺腺嘌呤二核苷酸合成聚（ADP - 核糖）的酶的活性。2. 这两种核酶的最高比活性出现在不同类别的细胞核中。研究表明，在非常年幼和成熟的大鼠中，DNA合成与烟酰胺单核苷酸腺苷酸转移酶活性之间存在相关性，但在中年大鼠中这种相关性不太明显。催化聚（ADP - 核糖）形成的酶的最高活性存在于参与RNA合成的细胞核中。3. 讨论了这些结果与烟酰胺腺嘌呤二核苷酸代谢的关系。
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