Jarumilinta R, Maegraith B G
Bull World Health Organ. 1969;41(2):269-73.
In spite of extensive studies of the pathogenic activities of Entamoeba histolytica upon animal hosts by many investigators, the factors that govern the pathogenesis of the parasite are still largely unknown. Attempts have been made to determine the factors concerned in the pathogenicity of certain strains of E. histolytica from the aspect of parasite itself and from the point of view of its interaction with the host. The enzyme content of the trophozoites of the amoebae examined has been studied in detail, both in the living organism and in its extracts. The total patterns of proteolytic enzymes and of certain other enzymes were determined to establish whether it was possible to define the invasiveness of the various strains of E. histolytica already established as pathogenic by other workers or in our laboratories. It was found impossible to distinguish clearly between the so-called "pathogenic" and "non-pathogenic" strains of E. histolytica by such means.
尽管许多研究人员对溶组织内阿米巴对动物宿主的致病活性进行了广泛研究，但控制该寄生虫发病机制的因素仍大多未知。人们已尝试从寄生虫自身以及其与宿主相互作用的角度来确定某些溶组织内阿米巴菌株致病性相关的因素。已对所检测的阿米巴滋养体在活生物体及其提取物中的酶含量进行了详细研究。确定了蛋白水解酶和某些其他酶的总体模式，以判断是否有可能界定其他研究人员或我们实验室已确定为致病性的各种溶组织内阿米巴菌株的侵袭性。结果发现，通过这种方式无法清楚地区分所谓的溶组织内阿米巴“致病”菌株和“非致病”菌株。
