类风湿因子与感染性单纯疱疹病毒 - 抗体复合物的相互作用。
Interaction of rheumatoid factor with infectious herpes simplex virus-antibody complexes.
作者信息
Ashe W K, Daniels C A, Scott G S, Notkins A L
出版信息
Science. 1971 Apr 9;172(3979):176-7. doi: 10.1126/science.172.3979.176.
Rheumatoid factor, a human immunoglobulin of the IgM class, failed to attach to herpes simplex virus but did attach to infectious complexes composed of herpes simplex virus and antibody to herpes simplex virus. These newly formed complexes of infectious virus, antiviral antibody, and rheumatoid factor could be neutralized by complement or by antibody to human IgM. The ability of rheumatoid factor to enhance virus neutralization in the presence of complement represents a hitherto unrecognized biological role for rheumatoid factor.
类风湿因子是一种IgM类的人类免疫球蛋白，它不能附着于单纯疱疹病毒，但能附着于由单纯疱疹病毒和单纯疱疹病毒抗体组成的感染性复合物。这些由感染性病毒、抗病毒抗体和类风湿因子新形成的复合物可被补体或抗人IgM抗体中和。在补体存在的情况下，类风湿因子增强病毒中和作用的能力代表了类风湿因子一种迄今未被认识的生物学作用。
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