钙作为促肾上腺皮质激素对肾上腺蛋白质合成作用的介质。

Calcium as a mediator of adrenocorticotrophic hormone action on adrenal protein synthesis.

作者信息

Farese R V

出版信息

Science. 1971 Jul 30;173(3995):447-50. doi: 10.1126/science.173.3995.447.

DOI:10.1126/science.173.3995.447

Abstract

Calcium stimulates leucine incorporation into protein during incubations of sections and cell-free preparations of the rat adrenal. Like adrenocorticotrophic hormone (ACTH) action, calcium enhances the transfer of amino acid from transfer RNA to protein. Stimulation of leucine incorporation by ACTH and cyclic adenosine monophosphate is best observed when sections are incubated in limiting calcium concentrations.

摘要

在大鼠肾上腺切片和无细胞制剂的孵育过程中，钙刺激亮氨酸掺入蛋白质中。与促肾上腺皮质激素（ACTH）的作用一样，钙增强了氨基酸从转运RNA到蛋白质的转移。当切片在有限的钙浓度下孵育时，ACTH和环磷酸腺苷对亮氨酸掺入的刺激作用最为明显。