磷脂在神经兴奋中的可能作用。
A possible role of phospholipid in nerve excitation.
作者信息
Wang J H
出版信息
Proc Natl Acad Sci U S A. 1970 Oct;67(2):916-20. doi: 10.1073/pnas.67.2.916.
Abstract
A possible role of phospholipid in regulating the ionic permeability of excitable membranes is proposed. It is assumed that each excitable transport channel in the nerve fiber is lined with two chains of phospholipid dipoles in either parallel or antiparallel directions; a molecular mechanism of nerve excitation is developed that is qualitatively consistent with most of the relevant observations reported in the literature.
摘要
本文提出了磷脂在调节可兴奋膜离子通透性方面可能发挥的作用。假定神经纤维中的每个可兴奋转运通道都由两条平行或反平行排列的磷脂偶极链构成；由此建立了一种神经兴奋的分子机制，该机制在定性上与文献中报道的大多数相关观察结果相符。
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A possible role of phospholipid in nerve excitation.磷脂在神经兴奋中的可能作用。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):916-20. doi: 10.1073/pnas.67.2.916.
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本文引用的文献
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On the cooperativity of biological membranes.论生物膜的协同性。
Proc Natl Acad Sci U S A. 1967 Feb;57(2):335-41. doi: 10.1073/pnas.57.2.335.
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On the localization of acetylcholine receptors.关于乙酰胆碱受体的定位
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Ionic movements and electrical activity in giant nerve fibres.巨神经纤维中的离子运动与电活动。
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Initiation and abolition of the action potential of a single node of Ranvier.单个郎飞结动作电位的起始与消除。
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On the biochemical mechanism of the visual process.关于视觉过程的生化机制
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Role of surface dipoles on axon membrane.
Science. 1969 Jan 17;163(3864):280-2. doi: 10.1126/science.163.3864.280.
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Electromagnetic emission at micron wavelengths from active nerves.活跃神经发出的微米波长电磁辐射。
Biophys J. 1968 Jun;8(6):731-4. doi: 10.1016/S0006-3495(68)86517-8.
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Light scattering and birefringence changes during nerve activity.神经活动期间的光散射和双折射变化。
Nature. 1968 May 4;218(5140):438-41. doi: 10.1038/218438a0.
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Chromophore transfer from lipid to protein in bovine rhodopsin.视黄醛在牛视紫红质中从脂质向蛋白质的转移
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