László F A, Mónus Z
Br J Exp Pathol. 1973 Jun;54(3):306-11.
A study was made in rats of the histological changes occurring in the kidney after temporary application of clamps to the renal pedicle following oestrogen, ACTH and cortisone treatments and removal of the pituitary. It was found that the tubular damage is increased to a small extent by oestrogen administration and to a more significant degree by ACTH and cortisone treatments. In rats hypophysectomized for several weeks the tubular necrosis either did not occur at all or only to an extremely mild degree. The investigations suggest that the change in sensitivity of the tubular epithelial cells to hypoxia may play a role in the development of the renal cortical necrosis induced by hormone treatment.
对大鼠进行了一项研究，观察在雌激素、促肾上腺皮质激素（ACTH）和可的松处理以及摘除垂体后，暂时钳夹肾蒂后肾脏发生的组织学变化。结果发现，给予雌激素会使肾小管损伤略有增加，而给予ACTH和可的松则会使损伤程度更显著。在摘除垂体数周的大鼠中，肾小管坏死要么根本不发生，要么仅为极其轻微的程度。这些研究表明，肾小管上皮细胞对缺氧敏感性的变化可能在激素治疗诱导的肾皮质坏死的发生中起作用。
