长期存活的伯基特淋巴瘤患者体内的爱泼斯坦-巴尔病毒相关膜反应性抗体
Epstein-Barr virus-associated membrane-reactive antibodies during long term survival Burkitt's lymphoma.
作者信息
Gunvén P, Klein G, Clifford P, Singh S
出版信息
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1422-6. doi: 10.1073/pnas.71.4.1422.
Antibodies to Epstein-Barr virus associated cell membrane antigens persisted or slowly decreased during prolonged uncomplicated survival of patients with Burkitt's lymphoma in remission. Serum was sampled from four patients within 6 months before recurrence occurring after the first year and preceded by remission during more than 6 months. Rapid and significant decreases of the antibodies before clinical recognition of the recurrences were found in three patients. The fourth patient had slowly increasing titers before relapse. Immune stimulant treatment during remission, with BCG (Bacille Calmette Guérin vaccine) or BCG + Bordetella pertussis, temporarily increased the antibody levels. Possible mechanisms for the observed titer changes before recurrence are discussed.
在缓解期的伯基特淋巴瘤患者长期无并发症存活期间，针对爱泼斯坦 - 巴尔病毒相关细胞膜抗原的抗体持续存在或缓慢下降。从4例患者中采集血清，这些患者在第一年之后复发前6个月内采样，且之前有超过6个月的缓解期。在3例患者中发现，在临床确认复发之前抗体迅速且显著下降。第四例患者在复发前抗体滴度缓慢上升。缓解期用卡介苗（卡介苗疫苗）或卡介苗 + 百日咳博德特氏菌进行免疫刺激治疗，可使抗体水平暂时升高。本文讨论了复发前观察到的滴度变化的可能机制。
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