单剂量给药后地高辛和β-乙酰基地高辛的生物利用度（作者译）

[Biological availability of digoxin and beta-acetyldigoxin after single-dose administration (author's transl)].

作者信息

Clasen R, Kemmeter H, Gilfrich H J

出版信息

Dtsch Med Wochenschr. 1979 Apr 13;104(15):543-6. doi: 10.1055/s-0028-1103942.

Abstract

The biological availability of digoxin tablets (Lanicor) and beta-acetyldigoxin tablets (Novodigal) was tested after single-dose administration. Plasma levels over 48 hours, the area under the blood-level curves and the cumulative urinary excretion over seven days served as a measure of biological availability. The area under the blood-level curve after 1.0 mg digoxin by mouth was 40.7 +/- 1.7 ng . ml-1 . h and after 1.0 mg beta-acetyldigoxin by mouth 39.1 +/- 1.4 ng . ml-1 h, compared with 56.1 +/- 1.4 after 1.0 mg digoxin intravenously. Seven days later 0.67 +/- 0.12 mg digoxin of the orally administered digoxin, 0.68 +/- 0.12 mg digoxin of the orally administered beta-acetyldigoxin and 0.81 +/- 0.08 mg of the intravenously administered digoxin were excreted in the urine. There was no significant difference in the biological availability of the two drugs (P greater than 0.05).

摘要

单次给药后，对地高辛片（Lanicor）和β-乙酰地高辛片（Novodigal）的生物利用度进行了测试。48小时内的血浆水平、血药浓度曲线下面积以及七天内的累积尿排泄量作为生物利用度的衡量指标。口服1.0mg地高辛后的血药浓度曲线下面积为40.7±1.7ng·ml⁻¹·h，口服1.0mgβ-乙酰地高辛后的血药浓度曲线下面积为39.1±1.4ng·ml⁻¹·h，而静脉注射1.0mg地高辛后的血药浓度曲线下面积为56.1±1.4。七天后，口服地高辛的0.67±0.12mg地高辛、口服β-乙酰地高辛的0.68±0.12mg地高辛以及静脉注射地高辛的0.81±0.08mg地高辛经尿液排出。两种药物的生物利用度无显著差异（P＞0.05）。