Brubakk A O, Bathen J
Eur J Clin Pharmacol. 1979 Mar 26;15(2):73-81. doi: 10.1007/BF00609868.
The acute haemodynamic effects of injected diazoxide (Hyperstat Schering) have been studied in 8 hypertensive subjects. Aortic blood pressure was measured and cardiac output and peripheral conductance were assessed continuously using a simulation model. In six of the patients pulmonary artery end-diastolic pressure was also measured. Blood pressure fell in all subjects 5-10 min after injection of the drug cardiac output increased in all patients studied. however, the initial change in cardiac output differed, as it decreased in two subjects and did not change in one. The largest initial increases in cardiac output were seen in the subjects with the highest pulmonary artery end-diastolic pressure. Patients with an initial decrease in cardiac output were those with the least compliant (stiffest) aortas. We consider that the responsiveness of the baroreceptors determines the size of the increase in cardiac output immediately after reduction of blood pressure by diazoxide. Thus in a patient with a stiff aorta, particularly at low cardiac filling pressure, diazoxide might cause a fall in blood pressure to an unacceptable level.
已对8名高血压患者注射二氮嗪（速降平，先灵公司生产）后的急性血流动力学效应进行了研究。测量主动脉血压，并使用模拟模型持续评估心输出量和外周血管阻力。6名患者还测量了肺动脉舒张末期压力。注射药物后5 - 10分钟，所有受试者的血压均下降，所有研究患者的心输出量均增加。然而，心输出量的初始变化有所不同，2名受试者的心输出量下降，1名受试者的心输出量无变化。心输出量初始增加最大的是肺动脉舒张末期压力最高的受试者。心输出量初始下降的患者是主动脉顺应性最差（最僵硬）的患者。我们认为，压力感受器的反应性决定了二氮嗪降压后心输出量立即增加的幅度。因此，在主动脉僵硬的患者中，特别是在低心脏充盈压时，二氮嗪可能会使血压降至不可接受的水平。
