Tolis G, Cruess S, Goldstein M, Friesen H G, Rochefort J G
Can Med Assoc J. 1974 Sep 21;111(6):553-6.
A 29-year-old woman with evidence of a craniopharyngioma and documented panhypopituitarism is described. Clinical and laboratory evaluation revealed deficiencies of follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, growth hormone, prolactin, adrenocorticotropic hormone and antidiuretic hormone. Prompt release of several pituitary hormones was noticed after administration of the hypothalamic releasing hormones FSH/LH-RF and thyrotropin-releasing hormone, whereas insulin-induced hypoglycemia, levodopa, chlorpromazine and clomiphene citrate, all of which act at the level of the hypothalamus, did not alter basal pituitary secretion. The patient's height of 60 inches, despite panhypopituitarism, and the interpretation of the above data are discussed in the light of current concepts regarding the dynamics of the hypothalamic-hypophyseal system.
本文描述了一名29岁患有颅咽管瘤并有全垂体功能减退记录的女性。临床和实验室评估显示促卵泡激素、促黄体生成素、促甲状腺激素、生长激素、催乳素、促肾上腺皮质激素和抗利尿激素缺乏。给予下丘脑释放激素促卵泡激素/促黄体生成素释放因子（FSH/LH-RF）和促甲状腺激素释放激素后，几种垂体激素迅速释放，而作用于下丘脑水平的胰岛素诱发低血糖、左旋多巴、氯丙嗪和枸橼酸氯米芬均未改变垂体基础分泌。结合当前关于下丘脑-垂体系统动力学的概念，讨论了该患者尽管存在全垂体功能减退但身高为60英寸的情况以及上述数据的解读。
