使用碳酸酐酶抑制剂使硬骨鱼虹鳟的眼部氧气浓缩机制短路。
Short circuiting the ocular oxygen concentrating mechanism in the teleost Salmo gairdneri using carbonic anhydrase inhibitors.
作者信息
Fairbanks M B, Hoffert J R, Fromm P O
出版信息
J Gen Physiol. 1974 Sep;64(3):263-73. doi: 10.1085/jgp.64.3.263.
Ocular oxygen concentration by the process of counter current multiplication in rainbow trout (Salmo gairdneri) was rapidly suppressed after intraperitoneal injections of the carbonic anhydrase inhibitor CL-11,366. The rapidity with which this drug acted suggested a short circuiting of the choroidal rete mirabile. A comparison was made between the time after injection of inhibitor at which oxygen concentrating ability was lost to the time after injection of inhibitor at which its presence in red blood cells, choroidal rete, pseudobranch, and retinal tissue was first noted. A scheme for the possible role of carbonic anhydrase from each of these tissues in the process of ocular oxygen concentration is given.
在虹鳟鱼（Salmo gairdneri）中，通过逆流倍增过程产生的眼内氧浓度在腹腔注射碳酸酐酶抑制剂CL - 11,366后迅速受到抑制。该药物作用的快速性表明脉络膜奇异网发生了短路。对注射抑制剂后失去氧浓缩能力的时间与首次在红细胞、脉络膜奇异网、伪鳃和视网膜组织中检测到抑制剂的时间进行了比较。给出了这些组织中碳酸酐酶在眼内氧浓缩过程中可能作用的示意图。
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