Kedar A, Wajsman Z, Moore R, Simpson L C, Murphy G P
Res Commun Chem Pathol Pharmacol. 1979 Jun;24(3):551-8.
The potential difference in survival due to scheduling of cyclophosphamide treatment was examined in A/J mice inoculated with neuroblastoma C1-1300 cells. Treatment was started on the third day post tumor implantation. There were four groups of animals each consisting of 30 mice: Group A, a control group, was injected with 0.3 cc of normal saline for a week. Group B was injected with cyclophosphamide 50 mg/kg/day every other day for five doses. This cycle was repeated in the same fashion starting on day 17. Group C was injected with cyclophosphamide 250 mg/kg on day 3 and this was repeated on day 17. Group D was injected with cyclophosphamide 50 mg/kg/day for five consecutive days. This cycle was repeated on day 17-21. The median survival for group B was 26.2 days (the same as the control group), for group C 47.7 days (87% increased survival) and for group D 63.2 days (143% increased survival with 30% possible cures). Twenty-three percent of the mice in group B died of pneumonia and another 23% had minor evidence of lung infection. Only three mice in this group had tumor at the time of death. The study suggests that the response of murine neuroblastoma as well as the development of pneumonia in A/J mice treated with cyclophosphamide might be schedule dependent.
在接种了神经母细胞瘤C1 - 1300细胞的A/J小鼠中，研究了环磷酰胺治疗时间安排对生存的潜在差异。在肿瘤植入后的第三天开始治疗。有四组动物，每组30只小鼠：A组为对照组，连续一周注射0.3 cc生理盐水。B组每隔一天注射50 mg/kg/天的环磷酰胺，共注射五剂。从第17天开始以同样的方式重复这个周期。C组在第3天注射250 mg/kg的环磷酰胺，并在第17天重复注射。D组连续五天注射50 mg/kg/天的环磷酰胺。这个周期在第17 - 21天重复。B组的中位生存期为26.2天（与对照组相同），C组为47.7天（生存期增加87%），D组为63.2天（生存期增加143%，有30%的可能治愈）。B组中23%的小鼠死于肺炎，另有23%有轻微的肺部感染迹象。该组只有三只小鼠在死亡时患有肿瘤。该研究表明，环磷酰胺治疗的A/J小鼠中，鼠神经母细胞瘤的反应以及肺炎的发生可能与治疗时间安排有关。
