骨肉瘤的转移扩散
Metastatic spread of osteosarcoma.
作者信息
Price C H, Jeffree G M
出版信息
Br J Cancer. 1973 Dec;28(6):515-24. doi: 10.1038/bjc.1973.181.
A study is presented of the rate of metastatic spread of osteosarcoma. The series consists of 123 tumours in long bones and 26 elsewhere in the skeleton. All tumours occurred in otherwise normal bones and were histologically proven. With a few stated exceptions all the cases were consecutively registered.Both the mean disease-free interval from the time of starting treatment and the crude survival curves are given. The long bone cases are analysed by groups according to the method of treatment, the patient's sex, age and tumour site. There were too few tumours of all other sites to warrant this discriminative treatment. Whilst the results of surgical treatment are better than for radiotherapy or a combined technique, the differences are not statistically significant and the information is recorded primarily to assist the evaluation of new forms of treatment of occult and overt metastases. Some problems in connection with such clinical trials are discussed briefly.
本文介绍了一项关于骨肉瘤转移扩散速率的研究。该系列包括123例长骨肿瘤和26例骨骼其他部位的肿瘤。所有肿瘤均发生于其他方面正常的骨骼，且经组织学证实。除少数明确说明的例外情况外，所有病例均连续登记。给出了从开始治疗起的平均无病间隔时间和粗略生存曲线。长骨病例根据治疗方法、患者性别、年龄和肿瘤部位分组进行分析。其他所有部位的肿瘤数量太少，无法进行这种区分性分析。虽然手术治疗的结果优于放疗或联合治疗技术，但差异无统计学意义，记录这些信息主要是为了辅助评估隐匿性和显性转移的新治疗形式。简要讨论了与此类临床试验相关的一些问题。
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