与镰状细胞贫血相关的小红细胞症

Microcytosis associated with sickle cell anemia.

作者信息

Glader B E, Propper R D, Buchanan G R

出版信息

Am J Clin Pathol. 1979 Jul;72(1):63-4. doi: 10.1093/ajcp/72.1.63.

DOI:10.1093/ajcp/72.1.63

Abstract

Sickle cell (Hb SS) anemia is considered a normochromic-normocytic hemolytic disorder. In 53 patients with Hb SS (mean reticulocyte values 16.8%), the authors observed that mean corpuscular hemoglobin (MCH) was 29.8 +/- 2.4 mu microgram and mean corpuscular hemoglobin (MCV) was 88.1 +/- 6.8 cu micrometers. In contrast, patients in a comparable hemolytic-disease group unrelated to hemoglobinopathies (mean reticulocyte count = 15.7%) had a higher MCH (33.0 +/- 1.8 mu microgram) and larger MCV (97 +/- 5.3 cu micrometers). These data indicate that Hb SS disease is associated with "relative microcytosis," presumably a consequence of reduced hemoglobin production.

摘要

镰状细胞（Hb SS）贫血被认为是一种正色素正细胞性溶血性疾病。在53例Hb SS患者（平均网织红细胞值为16.8%）中，作者观察到平均红细胞血红蛋白含量（MCH）为29.8±2.4微微克，平均红细胞体积（MCV）为88.1±6.8立方微米。相比之下，在一组与血红蛋白病无关的类似溶血性疾病患者中（平均网织红细胞计数 = 15.7%），MCH较高（33.0±1.8微微克），MCV较大（97±5.3立方微米）。这些数据表明，Hb SS病与“相对性小红细胞症”有关，推测这是血红蛋白生成减少的结果。