性连锁致死性疾病中的遗传漂变。

Slatkin M, Thomson G, Sawyer S

Am J Hum Genet. 1979 Mar;31(2):156-60.

A model is considered to calculate effects of genetic drift on the expected proportion of new mutants amongst males affected by a sex-linked recessive lethal. We show how to relate the number of cases of the disorder in males to the expected deviations from the deterministic value of the proportion of new mutants. For small values of alpha (= 3N mu), where N is the size of the female population, and mu is the mutation rate from wild-type to lethal allele, the standard deviation (SD) of the proportion of new mutants is large. However, if alpha more than 50, the potential effect of genetic drift is probably less important than the many other sources of error and bias.

考虑使用一个模型来计算遗传漂变对受X连锁隐性致死影响的男性中新突变体预期比例的影响。我们展示了如何将男性中该疾病的病例数与新突变体比例的确定性值的预期偏差联系起来。对于较小的α值（= 3Nμ，其中N是雌性群体的大小，μ是从野生型到致死等位基因的突变率），新突变体比例的标准差（SD）很大。然而，如果α大于50，遗传漂变的潜在影响可能不如许多其他误差和偏差来源重要。