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Perifusion of isolated rat islets in vitro. Participation of the microtubular system in the biphasic release of insulin.

作者信息

Lacy P E, Walker M M, Fink C J

出版信息

Diabetes. 1972 Oct;21(10):987-98. doi: 10.2337/diab.21.10.987.

DOI:10.2337/diab.21.10.987

PMID:4561331

Abstract

摘要

相似文献

Perifusion of isolated rat islets in vitro. Participation of the microtubular system in the biphasic release of insulin.

Diabetes. 1972 Oct;21(10):987-98. doi: 10.2337/diab.21.10.987.

Effect of cytochalasin B on the biphasic release of insulin in perifused rat islets.

Endocrinology. 1973 May;92(5):1458-68. doi: 10.1210/endo-92-5-1458.

Morphological relations between rat -secretory granules and the microtubular-microfilament system during sustained insulin release in vitro.

J Anat. 1973 Apr;114(Pt 3):421-37.

Insulin components released by the normal and subtotal degranulated perifused islets of Langerhans of the rat.

Acta Endocrinol (Copenh). 1975 Mar;78(3):524-30. doi: 10.1530/acta.0.0780524.

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Diabetologia. 1982 May;22(5):301-8. doi: 10.1007/BF00253571.

Effect of alloxan on insulin secretion in isolated rat islets perifused in vitro.

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Morphometric studies of secretory granule distribution and association with microtubules in beta-cells of rat islets during glucose stimulation.

Diabetes. 1987 Aug;36(8):905-13. doi: 10.2337/diab.36.8.905.

Role of microtubules in the phasic pattern of insulin release.

Ann N Y Acad Sci. 1975 Jun 30;253:630-52. doi: 10.1111/j.1749-6632.1975.tb19234.x.

Effects of anti-microtubular agents on alloxan stimulation and inhibition of glucose-induced insulin release in vitro.

Hiroshima J Med Sci. 1982 Jun;31(2):91-5.

The stimulus-secretion coupling of glucose-induced insulin release. V. The participation of a microtubular-microfilamentous system.

Diabetes. 1971 May;20(5):257-65. doi: 10.2337/diab.20.5.257.

引用本文的文献

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Perifusion of isolated rat islets in vitro. Participation of the microtubular system in the biphasic release of insulin.

作者信息

Lacy P E, Walker M M, Fink C J

出版信息

Diabetes. 1972 Oct;21(10):987-98. doi: 10.2337/diab.21.10.987.

DOI:10.2337/diab.21.10.987

PMID:4561331

Abstract

摘要

相似文献

Perifusion of isolated rat islets in vitro. Participation of the microtubular system in the biphasic release of insulin.

Diabetes. 1972 Oct;21(10):987-98. doi: 10.2337/diab.21.10.987.

Effect of cytochalasin B on the biphasic release of insulin in perifused rat islets.

Endocrinology. 1973 May;92(5):1458-68. doi: 10.1210/endo-92-5-1458.

Morphological relations between rat -secretory granules and the microtubular-microfilament system during sustained insulin release in vitro.

J Anat. 1973 Apr;114(Pt 3):421-37.

Insulin components released by the normal and subtotal degranulated perifused islets of Langerhans of the rat.

Acta Endocrinol (Copenh). 1975 Mar;78(3):524-30. doi: 10.1530/acta.0.0780524.

Microtubules, microfilaments and insulin-secretion.

Diabetologia. 1982 May;22(5):301-8. doi: 10.1007/BF00253571.

Effect of alloxan on insulin secretion in isolated rat islets perifused in vitro.

Diabetes. 1974 Jun;23(6):517-24. doi: 10.2337/diab.23.6.517.

Morphometric studies of secretory granule distribution and association with microtubules in beta-cells of rat islets during glucose stimulation.

Diabetes. 1987 Aug;36(8):905-13. doi: 10.2337/diab.36.8.905.

Role of microtubules in the phasic pattern of insulin release.

Ann N Y Acad Sci. 1975 Jun 30;253:630-52. doi: 10.1111/j.1749-6632.1975.tb19234.x.

Effects of anti-microtubular agents on alloxan stimulation and inhibition of glucose-induced insulin release in vitro.

Hiroshima J Med Sci. 1982 Jun;31(2):91-5.

The stimulus-secretion coupling of glucose-induced insulin release. V. The participation of a microtubular-microfilamentous system.

Diabetes. 1971 May;20(5):257-65. doi: 10.2337/diab.20.5.257.

引用本文的文献

Assessing the Rate-Dependence of the First Phase of Glucose-Stimulated Insulin Secretion: Dynamic Perifusion Studies with Isolated Human Pancreatic Islets.

bioRxiv. 2025 Jul 4:2025.07.01.662581. doi: 10.1101/2025.07.01.662581.

Hypertonicity during a rapid rise in D-glucose mediates first-phase insulin secretion.

Front Endocrinol (Lausanne). 2024 Jun 26;15:1395028. doi: 10.3389/fendo.2024.1395028. eCollection 2024.

A versatile pumpless multi-channel fluidics system for maintenance and real-time functional assessment of tissue and cells.

Cell Rep Methods. 2023 Nov 20;3(11):100642. doi: 10.1016/j.crmeth.2023.100642. Epub 2023 Nov 13.

Maintaining and Assessing Various Tissue and Cell Types of the Eye Using a Novel Pumpless Fluidics System.

J Vis Exp. 2023 Jul 14(197). doi: 10.3791/65399.

Microtubules in Pancreatic β Cells: Convoluted Roadways Toward Precision.

Front Cell Dev Biol. 2022 Jul 8;10:915206. doi: 10.3389/fcell.2022.915206. eCollection 2022.

Microtubules regulate pancreatic β-cell heterogeneity via spatiotemporal control of insulin secretion hot spots.

Elife. 2021 Nov 16;10:e59912. doi: 10.7554/eLife.59912.

Fluidics system for resolving concentration-dependent effects of dissolved gases on tissue metabolism.

Elife. 2021 Nov 4;10:e66716. doi: 10.7554/eLife.66716.

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Cells. 2021 Jan 19;10(1):191. doi: 10.3390/cells10010191.

Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice.

Cell Calcium. 2021 Mar;94:102339. doi: 10.1016/j.ceca.2020.102339. Epub 2020 Dec 28.

Insulin granule biogenesis and exocytosis.

Cell Mol Life Sci. 2021 Mar;78(5):1957-1970. doi: 10.1007/s00018-020-03688-4. Epub 2020 Nov 4.