Holub B J, Piekarski J
Lipids. 1979 Jun;14(6):529-32. doi: 10.1007/BF02533526.
The conversion of 2-acyl-sn-glycero-3-phosphorylinositol into phosphatidylinositol via acyl-CoA: 2-acyl-sn-glycero-3-phosphorylinositol acyltransferase activity was found to occur in rat liver microsomes. Over a wide range of conditions, stearic acid was preferred over palmitate by the acyltransferase when these acids were presented in mixtures as acyl-CoA derivatives. The potential importance of this enzyme activity for the entry of stearic acid into the 1-position of hepatic phosphatidylinositol is further supported by its greater preference for stearate relative to the acyl-CoA:2-acyl-sn-glycero-3-phosphorylcholine acyltransferase under certain assay conditions.
通过酰基辅酶A：2-酰基-sn-甘油-3-磷酸肌醇酰基转移酶活性将2-酰基-sn-甘油-3-磷酸肌醇转化为磷脂酰肌醇的过程被发现存在于大鼠肝脏微粒体中。在广泛的条件下，当这些酸以酰基辅酶A衍生物的混合物形式存在时，酰基转移酶优先选择硬脂酸而非棕榈酸。在某些测定条件下，相对于酰基辅酶A：2-酰基-sn-甘油-3-磷酸胆碱酰基转移酶，该酶活性对硬脂酸的偏好性更强，这进一步支持了这种酶活性对于硬脂酸进入肝脏磷脂酰肌醇1位的潜在重要性。
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