Carp J S, Anderson R J
Pharmacol Biochem Behav. 1979 Apr;10(4):513-20. doi: 10.1016/0091-3057(79)90226-0.
Unanesthetized adult cats were evaluated for suprasegmental reflex activity and motor skills before and after administration of chlorpromazine (0.0625--0.5 mg/kg) alone and in combination with phenytoin (20 mg/kg). The greatest deficits were seen in the tests of balance and corrdination in which half the animals failed to match their control responses after administration of chlorpromazine and phenytoin. The impairment was most noticeable with the most stringent test (walking a 4 cm wide beam), and the effects of the two drugs were additive. Although there was no effect of either drug on muscle strength, the two drugs in combination depressed the animals' motivational state, making them less willing to work against imposed loads. Neither drug, alone or in combination, altered responses to the flexor reflex, blind placing, the hopping response or visually aided placing. It is concluded that the effects of chlorpromazine and phenytoin on motor control are selective for the CNS loci which control balance and coordination. Although the two drugs produce additive responses, the deficits occur only at doses which are well above those needed for clinical efficacy and thus may not pose a problem in their long term clinical use.
在未麻醉的成年猫单独使用氯丙嗪（0.0625 - 0.5毫克/千克）以及与苯妥英钠（20毫克/千克）联合使用前后，对其节段上反射活动和运动技能进行评估。在平衡和协调测试中观察到最大的缺陷，其中一半的动物在使用氯丙嗪和苯妥英钠后无法达到其对照反应。在最严格的测试（在4厘米宽的横梁上行走）中，损伤最为明显，并且两种药物的作用是相加的。虽然两种药物对肌肉力量均无影响，但联合使用时会降低动物的动机状态，使它们不太愿意对抗施加的负荷工作。单独或联合使用这两种药物均未改变对屈肌反射、盲目放置、跳跃反应或视觉辅助放置的反应。得出的结论是，氯丙嗪和苯妥英钠对运动控制的影响对控制平衡和协调的中枢神经系统位点具有选择性。虽然两种药物产生相加反应，但缺陷仅在远高于临床疗效所需剂量时出现，因此在其长期临床使用中可能不会构成问题。
