Abt K
Pharmakopsychiatr Neuropsychopharmakol. 1979 Mar;12(2):228-36. doi: 10.1055/s-0028-1094614.
Assuming already condensed data from the EEG power spectra, problems arising with the statistical analysis of such data in comparative pharmaco-EEG trials are discussed. Since, in general, there is only a limited number of subjects available in a study to evaluate and compare the effects of a number of drugs by means of the EEG, the experimental design is usually of the cross-over type. With respect to this design, the requirements for the application and for the appropriate analysis are stated. Further, the problems are indicated which arise when the number of subjects is not a multiple of the number of drugs and/or when there are missing values. Finally, the topic of repeated null hypothesis testing and the inflation of the overall significance level is treated. Suggestions are made how to at least partly avoid the indicated problems at the present stage of methodological statistical research.
假设已对脑电图功率谱数据进行了浓缩，本文讨论了在比较药物脑电图试验中对此类数据进行统计分析时出现的问题。由于一般来说，在一项研究中可用于通过脑电图评估和比较多种药物效果的受试者数量有限，实验设计通常为交叉类型。针对这种设计，阐述了应用要求和适当的分析方法。此外，还指出了受试者数量不是药物数量的倍数和/或存在缺失值时出现的问题。最后，探讨了重复零假设检验和总体显著性水平膨胀的问题。在方法学统计研究的现阶段，就如何至少部分避免上述问题提出了建议。
