Lifschytz E, Lindsley D L
Proc Natl Acad Sci U S A. 1972 Jan;69(1):182-6. doi: 10.1073/pnas.69.1.182.
Inactivation of the single X chromosome in the primary spermatocytes of species with heterogametic males is postulated as a basic control mechanism on the chromosomal level that is required for normal spermatogenesis. This view is supported by (a) cytological observations of X-chromosome allocycly in the primary spermatocytes of all male-heterogametic organisms that were adequately examined, (b) autoradiographic evidence of early cessation of transcription by the X chromosome in the mouse and three species of grasshopper, and (c) the male sterility of animals with certain X-chromosome rearrangements that cannot be attributed to misfunction of specific genes. X-chromosome inactivation during spermatogenesis is proposed as the ideal system for studies of genetic control at the chromosomal level.
在雄性异配性别的物种中，初级精母细胞中的单条X染色体失活被假定为染色体水平上的一种基本调控机制，这是正常精子发生所必需的。这一观点得到了以下几方面的支持：(a) 对所有经过充分检查的雄性异配性生物的初级精母细胞中X染色体异时性的细胞学观察；(b) 小鼠和三种蝗虫中X染色体转录早期停止的放射自显影证据；(c) 某些X染色体重排的动物的雄性不育，而这种不育不能归因于特定基因的功能异常。精子发生过程中的X染色体失活被认为是研究染色体水平遗传调控的理想系统。
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