Overton D A
Science. 1979 Aug 17;205(4407):720-1. doi: 10.1126/science.462182.
Rats were trained to discriminate drug from no-drug conditions in a two-lever operant task. Moderately high dosages were used initially. Whenever the discrimination was learned, training was continued with progressively reduced dosages. Eventually the rats discriminated extremely low doses of phenobarbital, chlordiazepoxide, cyclazocine, and fentanyl.
在一项双杠杆操作性任务中，训练大鼠区分用药和未用药状态。最初使用中等偏高剂量。一旦学会辨别，就用逐渐降低的剂量继续训练。最终，大鼠能够辨别极低剂量的苯巴比妥、氯氮卓、环唑辛和芬太尼。
