博来霉素对枯草芽孢杆菌的作用方式。
Mode of action of phleomycin on Bacillus subtilis.
作者信息
Reiter H, Milewskiy M, Kelley P
出版信息
J Bacteriol. 1972 Aug;111(2):586-92. doi: 10.1128/jb.111.2.586-592.1972.
Abstract
Phleomycin appears to act on the cell wall and membrane to induce the release of membrane-associated deoxyribonucleic acid (DNA) and the degradation of the DNA. Degradation occurs in a series of energy-requiring endonuclease and exonuclease reactions. These produce, first, single-strand breaks, then double-strand breaks, and finally almost complete solubilization of the cellular DNA. The in vivo inhibition of DNA synthesis by phleomycin is probably a secondary effect caused by the destruction of template DNA.
摘要
博来霉素似乎作用于细胞壁和细胞膜，诱导膜相关脱氧核糖核酸（DNA）的释放以及DNA的降解。降解发生在一系列需要能量的内切核酸酶和外切核酸酶反应中。这些反应首先产生单链断裂，然后是双链断裂，最终细胞DNA几乎完全溶解。博来霉素在体内对DNA合成的抑制可能是由模板DNA的破坏引起的次级效应。
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