喂食乙硫氨酸对大鼠单次口服甲基汞剂量留存率的影响。
The effect of ethionine feeding on the retention of a single per os dose of methyl mercury on rat.
作者信息
Pekkanen T J, Salminen K
出版信息
Acta Vet Scand. 1972;13(3):319-22. doi: 10.1186/BF03547049.
Six adult female rats were daily fed a diet containing DL-ethionine during three weeks. One daily rat dose was 30 mg of ethionine. Six similar rats, the controls, were kept on the same diet without ethionine. On the 21st day of the experiment all rats were given one dose of Hg labeled methyl mercury by stomach tube. Each rat received 163 µg in terms of metallic mercury. Ninety hrs. after the mercury administration all rats were sacrificed and the mercury contents of the brains, livers, caudal femoral muscles, erythrocytes and blood plasma were determined. The mean plasma mercury content was significantly (P<0.01) greater in the ethionine fed rats when compared to the controls.
六只成年雌性大鼠连续三周每日喂食含DL-乙硫氨酸的饲料。大鼠每日乙硫氨酸剂量为30毫克。另外六只相似的大鼠作为对照，喂食不含乙硫氨酸的相同饲料。在实验的第21天，所有大鼠通过胃管给予一剂汞标记的甲基汞。每只大鼠摄入的金属汞量为163微克。给予汞后90小时，处死所有大鼠，测定脑、肝、尾股肌、红细胞和血浆中的汞含量。与对照组相比，喂食乙硫氨酸的大鼠血浆汞平均含量显著更高（P<0.01）。
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