Kerjaschki D, Krisch K, Sleyter U B, Umrath W, Jakesz R, Depisch D, Kokoschka R, Hörandner H
Am J Pathol. 1979 Jul;96(1):207-26.
Tight junctions of normal human epithelium comprise 6--8 intramembranous ridges. Tight junctions of adenomas and one case of follicular carcinoma were morphologically identical with normal controls. Another follicular carcinoma (clinically less malignant than the case mentioned above), however, showed loss of junctional polarity with spreading of ridges on lateral cell membranes. One case of papillary carcinoma (clinically low malignancy) displayed only focal attenuations of the tight junction belt. Another more malignant tumor of the same histologic type showed breaks of ridges and focal interruptions of the tight junction meshwork. Cell membranes of two anaplastic carcinomas of high malignancy were completely devoid of tight junction ridges. We conclude that tight junction alterations are not necessarily implicated in malignant transformation and that they correspond with tumor differentiation rather than directly with a single parameter of thyroid tumor malignancy.
正常人类上皮细胞的紧密连接由6 - 8条膜内嵴组成。腺瘤和1例滤泡癌的紧密连接在形态上与正常对照相同。然而，另一例滤泡癌（临床上恶性程度低于上述病例）显示连接极性丧失，嵴在细胞膜侧面扩散。1例乳头状癌（临床上低恶性）仅表现为紧密连接带的局灶性变薄。同一组织学类型的另一个恶性程度更高的肿瘤显示嵴断裂和紧密连接网络的局灶性中断。2例高恶性间变性癌的细胞膜完全没有紧密连接嵴。我们得出结论，紧密连接改变不一定与恶性转化有关，它们与肿瘤分化相关，而不是直接与甲状腺肿瘤恶性程度的单一参数相关。
