Vasquez M, Chuquimia R, Shantha N, Khan M, Narula O S
Br Heart J. 1979 Jun;41(6):709-15. doi: 10.1136/hrt.41.6.709.
In 35 patients aged 18 to 69 years (mean 48) with clinical, electrocardiographic, or electrophysiological evidence of normal sinus node function, the effect of intravenous propranolol (0.1 mg/kg) was assessed on 3 indices of sinus node function. The drug significantly prolonged sinus node cycle length (12%), slightly prolonged the corrected sinus node recovery time (15%), and slightly but insignificantly lengthened sinuatrial conduction time. Propranolol may be administered safely in patients with normal sinus node function without the fear of producing severe sinus bradycardia, sinuatrial block, sinuatrial pauses, or prolonged sinus asystole, after spontaneous or stimulation-induced conversion of a tachycardia.
在35例年龄为18至69岁（平均48岁）、具有临床、心电图或电生理证据表明窦房结功能正常的患者中，评估了静脉注射普萘洛尔（0.1mg/kg）对窦房结功能3项指标的影响。该药显著延长了窦房结周期长度（12%），轻微延长了校正窦房结恢复时间（15%），并轻微但不显著地延长了窦房传导时间。在心动过速自发或刺激诱发转复后，普萘洛尔可安全地用于窦房结功能正常的患者，而无需担心会产生严重窦性心动过缓、窦房阻滞、窦房停搏或延长的窦性停搏。
