磷酸三甲苯酯对大鼠血清和组织酯酶活性的影响。
Effects of tricresylphosphate on esterase activity of rat serum and tissues.
作者信息
Manno M, Rigoni F, Bartolucci G B, Bianchi M, Mazzotta M
出版信息
Br J Ind Med. 1979 May;36(2):153-6. doi: 10.1136/oem.36.2.153.
Abstract
The effect of tricresylphosphate (TCP) was studied in vitro and in vivo on the rat liver and brain enzymes acetylcholinesterase (ACC), butyrylcholinesterase (CHE), arylesterase (ARE), aliesterase (ALI), and the microsomal nicotinamide-adenine dinucleotide phosphate oxidase (NADPH2-oxidase) system. The results show that, in the male rat, TCP given intraperitoneally induces an increase in liver microsomal ARE AND NADPH2-oxidase and a decrease in ALI and cholinesterase; no activation of ARE and NADPH2-oxidase is observed in female rats.
摘要
研究了磷酸三甲苯酯（TCP）在体外和体内对大鼠肝脏及脑内的乙酰胆碱酯酶（ACC）、丁酰胆碱酯酶（CHE）、芳基酯酶（ARE）、脂肪族酯酶（ALI）以及微粒体烟酰胺腺嘌呤二核苷酸磷酸氧化酶（NADPH2-氧化酶）系统的影响。结果表明，对于雄性大鼠，腹腔注射TCP会使肝脏微粒体ARE和NADPH2-氧化酶增加，而ALI和胆碱酯酶减少；在雌性大鼠中未观察到ARE和NADPH2-氧化酶的激活。
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