大鼠对苯基汞的代谢
The metabolism of phenylmercury by the rat.
作者信息
Daniel J W, Gage J C, Lefevre P A
出版信息
Biochem J. 1972 Oct;129(4):961-7. doi: 10.1042/bj1290961.
The metabolism of [U-(14)C]phenylmercury acetate was studied in the rat. After a single subcutaneous dose a small proportion is excreted unchanged in urine, and a larger amount in bile with some resorption from the gut. The greater part of the dose is broken down in the tissues to yield inorganic mercury which is excreted mainly in faeces, and conjugates of phenol and quinol are excreted in urine. In experiments in vitro phenylmercury is broken down by liver homogenates to release inorganic mercury and benzene; this reaction is effected by the soluble, but not the microsomal, fraction and does not require NADPH or NADH. No elemental mercury is formed under these conditions. It is probable that this reaction occurs in vivo and the benzene produced is rapidly converted into phenol and quinol by microsomal enzymes.
在大鼠体内研究了[U-(14)C]苯基醋酸汞的代谢情况。单次皮下给药后，一小部分以原形经尿液排出，而更多的则随胆汁排出，部分会从肠道重吸收。大部分剂量在组织中分解，产生无机汞，主要经粪便排出，苯酚和对苯二酚的结合物经尿液排出。在体外实验中，苯基汞被肝匀浆分解，释放出无机汞和苯；此反应由可溶部分而非微粒体部分完成，且不需要烟酰胺腺嘌呤二核苷酸磷酸（NADPH）或烟酰胺腺嘌呤二核苷酸（NADH）。在这些条件下不会生成元素汞。该反应很可能在体内发生，所产生的苯会迅速被微粒体酶转化为苯酚和对苯二酚。
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