Abbatiello E R, Mohrmann K
Clin Toxicol. 1979 Apr;14(4):401-6. doi: 10.3109/15563657909010602.
This research is primarily concerned with the effects of chronic low doses of carbon monoxide on fetal development. Carbon monoxide was administered daily by inhalation to female Swiss Webster mice from the beginning of gestation until term. Daily weights were recorded and carbon monoxide blood levels determined every 4 days. The number of offspring in each litter was recorded. At weaning, two males and two females from each litter were randomly picked for maze running studies. When the mice were 6 weeks old, they were tested daily, ten trials per day, in the maze until learning had occurred. The number of days required to learn the maze and the number of incorrect trials were recorded. While there was no significant increase in the number of days needed to learn the maze, there was a significant increase in the number of errors made by the experimental group during this time. This indicated that an increased effort was needed to learn the maze.
本研究主要关注慢性低剂量一氧化碳对胎儿发育的影响。从妊娠开始直至足月，每天通过吸入方式给雌性瑞士韦伯斯特小鼠施用一氧化碳。记录每日体重，并每4天测定一次一氧化碳血浓度。记录每窝的后代数量。断奶时，从每窝中随机挑选两只雄性和两只雌性进行迷宫奔跑研究。当小鼠6周龄时，每天在迷宫中对它们进行测试，每天十次试验，直至学会为止。记录学会迷宫所需的天数和错误试验的次数。虽然学会迷宫所需的天数没有显著增加，但在此期间实验组的错误次数显著增加。这表明学习迷宫需要付出更多努力。
