肾上腺皮质线粒体中特异性参与胆固醇侧链裂解反应的细胞色素P - 450。去污剂、醇类、胺类、磷脂、类固醇羟化酶抑制剂和类固醇底物所诱导的光谱变化，以及肾上腺铁氧化还原蛋白与细胞色素结合的条件。 - Suppr | 超能文献

Adrenal cortex mitochondrial cytochrome P-450 specific to cholesterol side chain cleavage reaction. Spectral changes induced by detergents, alcohols, amines, phospholipids, steroid hydroxylase inhibitors, and steroid substrates, and conditions for adrenodoxin binding to the cytochrome.

作者信息

Kido T, Arakawa M, Kimura T

出版信息

J Biol Chem. 1979 Sep 10;254(17):8377-85.

Abstract

摘要

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1

Adrenal cortex mitochondrial cytochrome P-450 specific to cholesterol side chain cleavage reaction. Spectral changes induced by detergents, alcohols, amines, phospholipids, steroid hydroxylase inhibitors, and steroid substrates, and conditions for adrenodoxin binding to the cytochrome.肾上腺皮质线粒体中特异性参与胆固醇侧链裂解反应的细胞色素P - 450。去污剂、醇类、胺类、磷脂、类固醇羟化酶抑制剂和类固醇底物所诱导的光谱变化，以及肾上腺铁氧化还原蛋白与细胞色素结合的条件。

J Biol Chem. 1979 Sep 10;254(17):8377-85.

2

The side-chain cleavage of cholesterol sulfate--III. The effect of adrenodoxin, membrane phospholipids and Tween 80 on the kinetics of oxidation of the sterol sulfate by a reconstituted cholesterol desmolase system.

J Steroid Biochem. 1986 Apr;24(4):909-16. doi: 10.1016/0022-4731(86)90453-x.

3

Mitochondrial cytochrome P-450scc. Mechanism of electron transport by adrenodoxin.线粒体细胞色素P-450侧链裂解酶。肾上腺皮质铁氧化还原蛋白的电子传递机制。

J Biol Chem. 1980 Apr 10;255(7):3057-61. doi: 10.1016/S0021-9258(19)85851-9.

4

Participation of the membrane in the side chain cleavage of cholesterol. Reconstitution of cytochrome P-450scc into phospholipid vesicles.膜在胆固醇侧链裂解中的作用。将细胞色素P-450scc重组到磷脂囊泡中。

J Biol Chem. 1979 Dec 10;254(23):12088-98.

5

Effects of phospholipid and detergent on the substrate specificity of adrenal cytochrome P-450scc. Substrate binding and kinetics of cholesterol side chain oxidation.磷脂和去污剂对肾上腺细胞色素P-450scc底物特异性的影响。底物结合及胆固醇侧链氧化动力学。

J Biol Chem. 1981 May 10;256(9):4407-17.

6

Cytochrome P450 in adrenocortical mitochondria.肾上腺皮质线粒体中的细胞色素P450

Mol Cell Biochem. 1979 Mar 5;24(1):21-43. doi: 10.1007/BF00220191.

7

Cytochrome P-450scc. Cardiolipin as an effector of activity of a mitochondrial cytochrome P-450.

J Biol Chem. 1981 May 25;256(10):4757-62.

8

22-Ketocholesterol. A potent competitive inhibitor of cytochrome P-450scc-dependent side-chain cleavage of cholesterol.22-酮胆固醇。一种对细胞色素P-450scc依赖性胆固醇侧链裂解具有强效竞争性抑制作用的物质。

Mol Pharmacol. 1983 May;23(3):743-7.

9

[Reconstitution of the cholesterol-hydroxylating system from adrenal cortex mitochondria by cytochrome P-450scc, adrenodoxin and the redox-mediator neutral red].[通过细胞色素P-450scc、肾上腺铁氧还蛋白和氧化还原介质中性红重构肾上腺皮质线粒体胆固醇羟化系统]

Biokhimiia. 1990 Sep;55(9):1553-62.

10

The formation of binary and ternary complexes of cytochrome P-450scc with adrenodoxin and adrenodoxin reductase.adrenodoxin complex. The implication in ACTH function.细胞色素P-450侧链裂解酶与肾上腺铁氧化还原蛋白及肾上腺铁氧化还原蛋白还原酶形成二元和三元复合物。肾上腺铁氧化还原蛋白复合物。其在促肾上腺皮质激素功能中的意义。

J Biol Chem. 1979 Dec 10;254(23):11806-15.

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1

Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents.治疗药物对纯化重组 CYP11A1 活性的抑制和刺激作用。

Mol Cell Endocrinol. 2013 May 22;371(1-2):100-6. doi: 10.1016/j.mce.2012.10.013. Epub 2012 Oct 23.

2

ACTH stimulation on cholesterol side chain cleavage activity of adrenocortical mitochondria. Transfer of the stimulus from plasma membrane to mitochondria.促肾上腺皮质激素对肾上腺皮质线粒体胆固醇侧链裂解活性的刺激作用。刺激从质膜向线粒体的传递。

Mol Cell Biochem. 1981 Apr 27;36(2):105-22. doi: 10.1007/BF02354909.