Andrews C J
J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):630-6. doi: 10.1136/jnnp.36.4.630.
The gait of normal subjects was examined electromyographically and the pattern was altered during preferential blockade of large nerve fibres to alternating activity in flexor and extensor muscles.The EMG activity was disrupted more in flexor than extensor muscles by preferential ischaemic blockade. Normal gait was associated with flexor contraction only when the foot was lifted and placed on the ground, whereas during ischaemic blockade flexor contraction continued during the interval between foot lifting and foot placement.The freezing' or blocking' gait in Parkinson's disease was found to be associated with coactivation of flexor and extensor muscles and this phenomenon occurred only in patients with features of flexion dystonia in the electromyographic recordings of their tonic stretch reflexes. Eight of nine patients with evidence of flexion dystonia showed a deterioration in their response to l-dopa therapy over a two year period, whereas four patients without flexion dystonia maintained their clinical improvement.
对正常受试者的步态进行了肌电图检查，在大神经纤维被优先阻断时，屈肌和伸肌的交替活动会改变步态模式。优先缺血性阻断使屈肌的肌电图活动比伸肌受到更大干扰。正常步态仅在脚抬起并着地时与屈肌收缩有关，而在缺血性阻断期间，屈肌收缩在脚抬起和着地的间隔期仍持续。帕金森病的“冻结”或“阻滞”步态被发现与屈肌和伸肌的共同激活有关，且这种现象仅在其强直性牵张反射的肌电图记录中有屈肌肌张力障碍特征的患者中出现。9名有屈肌肌张力障碍证据的患者中有8名在两年期间对左旋多巴治疗的反应恶化，而4名没有屈肌肌张力障碍的患者维持了临床改善。
