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新城疫病毒的热灭活。I. 血凝活性和神经氨酸酶活性的耦合灭活速率。

Thermal inactivation of Newcastle disease virus. I. Coupled inactivation rates of hemagglutinating and neuraminidase activities.

作者信息

Pierce J S, Haywood A M

出版信息

J Virol. 1973 Feb;11(2):168-76. doi: 10.1128/JVI.11.2.168-176.1973.

Abstract

The thermal stability of Newcastle disease virus has been characterized in terms of the rate constants for inactivation of hemagglutinating activity (HA), neuraminidase activity (NA), and infectivity. Inactivation of HA results in the concomitant loss of NA. Infectivity, however, is much more thermolabile. Disintegration of the virus particle is not responsible for the identical rate constants for inactivation of HA and NA, nor is their parallel inactivation uncoupled in envelope fragments produced by pretreating the virus with phospholipase-C. The data indicate that a common envelope factor(s) can influence the thermal stability of both activities.

摘要

新城疫病毒的热稳定性已根据血凝活性(HA)、神经氨酸酶活性(NA)和感染性失活的速率常数进行了表征。HA的失活会导致NA同时丧失。然而,感染性对热更不稳定。病毒颗粒的解体并非HA和NA失活速率常数相同的原因,在用磷脂酶-C预处理病毒产生的包膜片段中,它们的平行失活也未被解偶联。数据表明,一种共同的包膜因子可影响这两种活性的热稳定性。

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