Burek J D, Goldberg B, Hutchins G, Strandberg J D
Vet Pathol. 1979 Sep;16(5):553-66. doi: 10.1177/030098587901600508.
In pregnant Syrian hamsters (Mesocricetus auratus) used as an animal model for studying the migration of fetal trophoblasts and the associated changes in maternal blood vessels, intravascular trophoblasts migrated well beyond the blood vessels of the uterus and into the vessels of the mesometrium. They migrated beyond the decidua of the uterus, into the lumina of maternal uterine and mesometrial arteries, but not into veins. The arterial changes, which were often segmental, resembled those seen in the decidua and consisted of a replacement of normal smooth muscle cells by poorly differentiated stromal cells. Ultrastructurally, the trophoblasts were either above or below maternal endothelial cells. They occurred also as single or multiple layers within the lumina of arteries that lacked an endothelial lining. Apparent penetration of the elastic membrane by the fetal trophoblasts brought them into close apposition to maternal cells in the arterial wall. Histochemical studies showed heightened metabolic activity of the intravascular trophoblasts as suggested by strong histochemical reactions to nonspecific esterase, succinic dehydrogenase and the glycerophosphate dehydrogenase reactions. Thus, these metabolically active fetal trophoblasts actively migrate into the maternal arterial system, resulting in loss of endothelial cells and changes in the wall of the maternal arteries similar to those in the decidua at the uteroplacental junction.
在用作研究胎儿滋养层细胞迁移及母体血管相关变化动物模型的怀孕叙利亚仓鼠（金仓鼠）中，血管内滋养层细胞迁移至子宫血管之外，进入子宫系膜的血管。它们迁移至子宫蜕膜之外，进入母体子宫和子宫系膜动脉管腔，但未进入静脉。动脉变化通常呈节段性，类似于蜕膜中的变化，包括正常平滑肌细胞被分化不良的基质细胞取代。超微结构上，滋养层细胞位于母体内皮细胞之上或之下。它们也以单层或多层形式出现在缺乏内皮衬里的动脉管腔内。胎儿滋养层细胞明显穿透弹性膜，使其与动脉壁中的母体细胞紧密相邻。组织化学研究表明，血管内滋养层细胞代谢活性增强，这表现为对非特异性酯酶、琥珀酸脱氢酶和甘油磷酸脱氢酶反应有强烈的组织化学反应。因此，这些代谢活跃的胎儿滋养层细胞积极迁移至母体动脉系统，导致内皮细胞丢失以及母体动脉壁发生类似于子宫胎盘交界处蜕膜中的变化。
