QSAR of alkyl pyridinecarbonyldithiocarbazates as uncouplers of oxidative phosphorylation.

The structure-activity relationship for alkyl dithiocarbazates and alkyl pyridinecarbonyldithiocarbazates as oncouplers of oxidative phosphorylation in rat liver mitochondria has been studied using subsituent constants and regression analysis. As in various other uncouplers, the hydrophobic property of substituents gave a good correlation with their biological activities. 4-Pyridinecarbonyldithiocarbazates are the most active among the congeners studied.