钡诱导的大鼠骨骼肌麻痹及其与人类家族性周期性麻痹的关系。
Barium-induced skeletal muscle paralysis in the rat, and its relationship to human familial periodic paralysis.
作者信息
Schott G D, McArdle B
出版信息
J Neurol Neurosurg Psychiatry. 1974 Jan;37(1):32-9. doi: 10.1136/jnnp.37.1.32.
Abstract
An in vivo study of skeletal muscle paralysis induced by intravenous barium chloride has been made in curarized and non-curarized rats. The influence of potassium and calcium chlorides, propranolol, ouabain, and prior adrenalectomy on the paralysis has also been studied. Paralysis is found to be due to a direct effect on skeletal muscle, and to correlate well with the development of hypokalaemia. Possible mechanisms of action of barium are discussed, and attention is drawn to the similarity between barium poisoning and hypokalaemic familial periodic paralysis.
摘要
已经在箭毒化和未箭毒化的大鼠身上进行了静脉注射氯化钡引起骨骼肌麻痹的体内研究。还研究了氯化钾、氯化钙、普萘洛尔、哇巴因以及预先进行肾上腺切除术对麻痹的影响。发现麻痹是由于对骨骼肌的直接作用，并且与低钾血症的发展密切相关。讨论了钡的可能作用机制，并提请注意钡中毒与低钾性家族性周期性麻痹之间的相似性
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2
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