Nelson C S
Thorax. 1974 Jan;29(1):134-37. doi: 10.1136/thx.29.1.134.
, , 134-137. There is no specific treatment of fat embolism, whether the embolism is predominantly cerebral, pulmonary, renal or mesenteric. A 46-year-old man had fractured his right femur for the third time in December 1971. Seventy hours later he suddenly developed the cardiovascular, respiratory, and cerebral manifestations of post-traumatic fat embolism. His chest radiograph at the onset of symptoms was consistent with fat embolism. He underwent cardiac and pulmonary embolectomy on 7 December 1971 and made a most dramatic recovery. His haemobronchorrhoea, dyspnoea, tachypnoea, hyperpyrexia, and profound shock disappeared at the end of the operation. His only postoperative cerebral disturbance was mild disorientation. The pathophysiological changes accompanying fat embolism are due to toxic vasculitis and fat macroglobule aggregations blockading the pulmonary arterioles and capillaries. The blockading concept is the basis for cardiac and pulmonary fat embolectomy. Only a larger series embodying a multicentre trial will show whether or not cardiopulmonary fat embolectomy is a specific treatment of massive fat embolism. The purpose of this paper is to report on the technique and result of embolectomy for a suspected fat embolus following fracture of the femur.
,,134 - 137。脂肪栓塞无论主要累及脑、肺、肾还是肠系膜,均无特效治疗方法。一名46岁男性于1971年12月第三次发生右股骨骨折。70小时后,他突然出现创伤后脂肪栓塞的心血管、呼吸及脑部表现。症状发作时他的胸部X线片与脂肪栓塞相符。他于1971年12月7日接受了心脏及肺部栓子切除术,恢复情况极为显著。术中他的咯血、呼吸困难、呼吸急促、高热及严重休克均消失。术后他唯一的脑部异常是轻度定向障碍。脂肪栓塞伴随的病理生理变化是由于毒性血管炎及脂肪大球聚集阻塞肺动脉小分支和毛细血管所致。阻塞这一概念是心脏及肺部脂肪栓子切除术的基础。只有纳入多中心试验的更大样本系列研究才能表明心肺脂肪栓子切除术是否为大面积脂肪栓塞的特效治疗方法。本文旨在报告股骨骨折后疑似脂肪栓子的栓子切除术技术及结果。