脑栓塞与二尖瓣狭窄：使用和不使用抗凝剂的生存率
Cerebral embolism and mitral stenosis: survival with and without anticoagulants.
作者信息
Adams G F, Merrett J D, Hutchinson W M, Pollock A M
出版信息
J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):378-83. doi: 10.1136/jnnp.37.4.378.
Abstract
Eighty-four patients with mitral stenosis and cerebral embolism have been followed up for 20 years. Half of the series (those treated in the early years) had no anticoagulant treatment and half were given long-term warfarin therapy. Mortality rate and causes of death have been reviewed, and comparison of survival times of treated and untreated groups by life-table analysis bears out the immediate need for anticoagulants when a diagnosis of systemic embolism is established. It is wise to continue the treatment for six months but it may be reasonable to discontinue it after one year with patients who can be assured of regular review.
摘要
84例二尖瓣狭窄合并脑栓塞患者接受了20年的随访。该系列病例中有一半（早期治疗的患者）未接受抗凝治疗，另一半接受了长期华法林治疗。已对死亡率和死亡原因进行了回顾，通过寿命表分析对治疗组和未治疗组的生存时间进行比较，结果表明，一旦确诊为全身性栓塞，立即需要使用抗凝剂。持续治疗6个月是明智的，但对于能够保证定期复查的患者，在1年后停药可能也是合理的。
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