Chorzelski T, Kuch J
Clin Exp Immunol. 1969 Jun;4(6):691-5.
Immunofluorescence tests for circulating `pemphigus' antibodies incidentally revealed in the patient antibodies directed against the heart. Subsequent serial electrocardiograms confirmed two past cardiac infarctions, one a year and one a few weeks previously. Bi-weekly quantitative immunofluorescence tests demonstrated an initial high titre of anti-heart and pemphigus antibodies (1:320 and 1:80, respectively). Corticotherapy, which was prescribed for pemphigus before the establishment of myocardial infarction, gradually depressed the titres of the two kinds of antibodies to zero within 14 weeks. The absence of symptoms of a post-infarction syndrome in spite of the high titre of anti-heart antibodies might be explained in two ways: (1) the syndrome followed an abortive previously undiagnosed course, or (2) it failed to develop because the early institution of steroid therapy inhibited the effects of the possible immunological reaction.
对该患者进行循环“天疱疮”抗体的免疫荧光检测时,意外发现了针对心脏的抗体。随后连续的心电图证实既往有两次心肌梗死,一次发生在一年前,另一次发生在几周前。每两周进行的定量免疫荧光检测显示,抗心脏抗体和天疱疮抗体最初的滴度很高(分别为1:320和1:80)。在心肌梗死确诊前因天疱疮而进行的皮质激素治疗,在14周内逐渐将两种抗体的滴度降至零。尽管抗心脏抗体滴度很高,但未出现心肌梗死后综合征的症状,这可能有两种解释:(1)该综合征之前有过未被诊断出的顿挫病程,或者(2)由于早期使用类固醇治疗抑制了可能的免疫反应,该综合征未能发展。