Miyanaga Y
Nihon Seikeigeka Gakkai Zasshi. 1979 Jun;53(6):681-95.
In order to evaluate the role of the subchondral bone (cancellous bone) in the development and progression of the joint degeneration, osteoarthritis of the knee joint was produced experimentally in the rabbits and viscoelasticity and strength of the subchondral bone from the femoral medial condyle have been investigated along with the pathological, histological study of the joint. The viscoelastic spectrometer and the Instron type testing machine were used. As the first change after operation, osteophyte formation around the joint margin has been observed before the initiation of the degeneration of articular cartilage and there is a possibility that mechanical properties of subchondral bone such as high deformability and low elasticity to the mechanism of osteophyte formation. Subchondral bone softening with marked increase of ultimate strain and phase lag, marked decrease of compressive elastic modulus and ultimate stress precedes or occurs concurrently with the degeneration of the articular cartilage. These facts indicate the relationship between the mechanical properties of the subchondral bone and joint degeneration. Once the joint degeneration starts, degeneration continues progressively while the subchondral bone tends to become brittle. These changes may be considered as a kind of functional adaptation to the damage or denudation of articular cartilage. It is postulated that some architectural changes of the subchondral bone may provide alterations of the mechanical properties. Biomechanical roles of the subchondral bone is suggested as one of the factors in the joint degeneration.
为了评估软骨下骨（松质骨）在关节退变发展过程中的作用，通过实验诱导兔膝关节骨关节炎，并对股骨内侧髁软骨下骨的粘弹性和强度进行了研究，同时对关节进行了病理学和组织学研究。使用了粘弹性光谱仪和英斯特朗型试验机。术后首先观察到的变化是，在关节软骨退变开始之前，关节边缘就出现了骨赘形成，软骨下骨的力学性能如高变形性和低弹性可能参与了骨赘形成机制。软骨下骨软化，极限应变和相位滞后显著增加，压缩弹性模量和极限应力显著降低，先于关节软骨退变或与退变同时发生。这些事实表明了软骨下骨力学性能与关节退变之间的关系。一旦关节退变开始，退变会持续进展，而软骨下骨则趋于变脆。这些变化可被视为对关节软骨损伤或剥脱的一种功能适应。据推测，软骨下骨的一些结构变化可能导致力学性能改变。软骨下骨的生物力学作用被认为是关节退变的因素之一。
