半胱氨酸与烷化剂之间的协同作用。
Synergism between cysteine and alkylating agents.
作者信息
Rosenkranz H S, Carr H S, Zyroff J
出版信息
J Bacteriol. 1970 Jun;102(3):672-6. doi: 10.1128/jb.102.3.672-676.1970.
Abstract
Contrary to expectation, l-cysteine did not protect Escherichia coli from the lethal action of two monofunctional alkylating agents (nitrosomethylurethane and methylmethane sulfonate). The antibacterial action of these compounds was actually greatly enhanced by l-cysteine. This synergistic effect was also exhibited, to some extent, by d-cysteine but not by homocysteine, S-methylcysteine, or serine. The synergistic action between methylating agents and l-cysteine was not due to the formation of S-methylcysteine. l-Cysteine had no effect on the bacteriostatic action of ethylmethane sulfonate.
摘要
与预期相反，L-半胱氨酸并不能保护大肠杆菌免受两种单功能烷基化剂（亚硝基甲基脲和甲磺酸甲酯）的致死作用。实际上，L-半胱氨酸大大增强了这些化合物的抗菌作用。这种协同效应在一定程度上也由D-半胱氨酸表现出来，但同型半胱氨酸、S-甲基半胱氨酸或丝氨酸则没有。甲基化剂与L-半胱氨酸之间的协同作用并非由于S-甲基半胱氨酸的形成。L-半胱氨酸对甲磺酸乙酯的抑菌作用没有影响。
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