大鼠实验性肾脏疾病中肾脏抗原的尿排泄
Urinary excretion of kidney antigens in experimental renal diseases of the rat.
作者信息
Rosenmann E, Dishon T, Durst A, Boss J H
出版信息
Br J Exp Pathol. 1971 Aug;52(4):388-94.
Urine samples of healthy rats and animals with experimentally induced nephropathies were tested with precipitating anti-kidney sera, which had been made relatively organ-specific by absorption with diverse tissues. Kidney antigens were not detected in unconcentrated urine of control rats. On the other hand, kidney antigens were demonstrated in the unconcentrated urine of a significant number of animals with toxic nephropathies, produced by mercuric chloride or uranyl nitrate, haemoglobinuric nephrosis, osmotic nephrosis, ischaemic parenchymal damage and acute hydronephrosis. The duration of urinary excretion of renal tissue constituents varied from one animal to another in the same group as well as from one experimental model to another. The described serological test may be of diagnostic and prognostic significance in the evaluation of diseases in which tissue breakdown occurs.
用经多种组织吸收而具有相对器官特异性的沉淀抗肾血清，对健康大鼠和实验性诱导肾病动物的尿液样本进行检测。在对照大鼠的未浓缩尿液中未检测到肾脏抗原。另一方面，在大量患有由氯化汞或硝酸铀酰引起的中毒性肾病、血红蛋白尿性肾病、渗透性肾病、缺血性实质损伤和急性肾积水的动物的未浓缩尿液中，证实存在肾脏抗原。同一组内不同动物以及不同实验模型之间，肾组织成分的尿排泄持续时间各不相同。所述血清学检测在评估发生组织破坏的疾病时可能具有诊断和预后意义。
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