Azzopardi J G, Evans D J
J Clin Pathol. 1971 Nov;24(8):744-52. doi: 10.1136/jcp.24.8.744.
Benign lymphoepithelial lesion (Mikulicz disease) is generally regarded as an inflammatory disorder of unknown aetiology, characterized by epimyoepithelial islands, and unrelated to malignant lymphoma. Five cases have been collected which show evidence at the same site of both Mikulicz disease and a malignant lymphoma. The latter took the form of reticulum-cell sarcoma or Hodgkin's disease. The two diseases were discovered simultaneously or the malignant lymphoma was detected at a subsequent date. The probable sequence of events is discussed. These cases are regarded as one of the best illustrations in man of an autoimmune disorder being followed by the development of malignant lymphoma. It is concluded that so-called benign lymphoepithelial lesion is not always innocuous and an attempt is made to establish histological criteria which might be regarded with suspicion in a particular case.
良性淋巴上皮病变（米库利奇病）通常被视为一种病因不明的炎症性疾病，其特征为肌上皮岛，与恶性淋巴瘤无关。本文收集了5例病例，这些病例显示在同一部位同时存在米库利奇病和恶性淋巴瘤。后者表现为网状细胞肉瘤或霍奇金病。两种疾病同时被发现，或者恶性淋巴瘤在随后被检测到。文中讨论了可能的事件顺序。这些病例被视为人类自身免疫性疾病继发恶性淋巴瘤发展的最佳例证之一。得出的结论是，所谓的良性淋巴上皮病变并非总是无害的，并尝试建立在特定病例中可能值得怀疑的组织学标准。
