有机硝酸盐对体外心肌耗氧量的影响。
Effect of organic nitrates on myocardial oxygen consumption in vitro.
作者信息
Levy J V
出版信息
Br J Pharmacol. 1970 Apr;38(4):743-8. doi: 10.1111/j.1476-5381.1970.tb09883.x.
Abstract
- Mannitol hexanitrate (MANHN), iditol hexanitrate and sorbitan tetranitrate, all at 442 muM, stimulate oxygen uptake by isolated rabbit atrial tissue.2. At the same concentration, glyceryl trinitrate decreased oxygen uptake, while isosorbide dinitrate and erythrityl tetranitrate had no effect.3. No simple correlation was found between the lipoid solubility or per cent nitration of these compounds and their effects on oxygen uptake.4. The stimulating effect of MANHN and its possible role as an uncoupler of oxidative phosphorylation is discussed.
摘要
甘露糖醇六硝酸酯（MANHN）、艾杜糖醇六硝酸酯和山梨醇四硝酸酯，浓度均为442μM时，均可刺激离体兔心房组织对氧的摄取。
相同浓度下，甘油三硝酸酯降低氧摄取，而异山梨醇二硝酸酯和赤藓醇四硝酸酯则无作用。
未发现这些化合物的类脂溶解度或硝化百分比与其对氧摄取的作用之间存在简单的相关性。
讨论了MANHN的刺激作用及其作为氧化磷酸化解偶联剂的可能作用。
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