人血浆纤维蛋白原及其他组分中的澳大利亚（肝炎相关）抗原。
The Australia (hepatitis-associated) antigen in fibrinogen and other fractions of human plasma.
作者信息
Zuckerman A J, Taylor P E, Bird R G, Russell S M
出版信息
J Clin Pathol. 1971 Feb;24(1):2-7. doi: 10.1136/jcp.24.1.2.
Human plasma containing the Australia (hepatitis-associated) antigen was fractionated by the cold ethanol method of Cohn, Strong, Hughes, Mulford, Ashworth, Melin, and Taylor (1946) and small aliquots were examined for the presence of this antigen by immunodiffusion and by electron microscopy. The findings were in general agreement with the postulated risk of transmitting hepatitis by blood derivatives. The Australia (hepatitis-associated) antigen was detected in fibrinogen, thrombin, and antihaemophilic globulin as well as in other fractions. The antigen was not found in gamma globulin (immunoglobulin fraction) nor in albumin.The use of radioiodinated fibrinogen for the diagnosis of deep vein thrombosis is discussed and it is concluded that the use of fibrinogen for diagnostic procedures should be assessed against the possible risk of hepatitis.
采用科恩、斯特朗、休斯、马尔福德、阿什沃思、梅林和泰勒（1946年）的冷乙醇法对含有澳大利亚（肝炎相关）抗原的人血浆进行分级分离，并通过免疫扩散和电子显微镜检查小份样品中该抗原的存在情况。研究结果总体上与血液制品传播肝炎的假定风险相符。在纤维蛋白原、凝血酶和抗血友病球蛋白以及其他分级分离物中检测到了澳大利亚（肝炎相关）抗原。在γ球蛋白（免疫球蛋白分级分离物）和白蛋白中未发现该抗原。讨论了使用放射性碘化纤维蛋白原诊断深静脉血栓形成的情况，并得出结论，应根据肝炎的潜在风险评估将纤维蛋白原用于诊断程序的情况。
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