一种用于特异性测定凝血酶原的新型显色测定法。
A new chromogenic assay for the specific determination of prothrombin.
作者信息
Francis J L
出版信息
J Clin Pathol. 1979 Jul;32(7):651-4. doi: 10.1136/jcp.32.7.651.
Abstract
A new method for the specific assay of prothrombin is described which utilises Taipan snake venom and the chromogenic substrate Tos-Gly-Pro-Arg-pNA (Chromozym TH). The method is sensitive and reproducible and shows good correlation with a conventional specific assay for prothrombin. The reaction is dependent on calcium ions and phospholipid, and is therefore sensitive to the coumarin-induced prothrombin defect. The assay is rapid and well suited for use in the routine coagulation laboratory.
摘要
本文描述了一种用于凝血酶原特异性测定的新方法，该方法利用太攀蛇毒和发色底物Tos-Gly-Pro-Arg-pNA（Chromozym TH）。该方法灵敏且可重复，与传统的凝血酶原特异性测定方法具有良好的相关性。该反应依赖于钙离子和磷脂，因此对香豆素诱导的凝血酶原缺陷敏感。该测定方法快速，非常适合在常规凝血实验室中使用。
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本文引用的文献
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