Mearns M B
Arch Dis Child. 1972 Feb;47(251):5-11. doi: 10.1136/adc.47.251.5.
Seventy-six patients with cystic fibrosis seen between 1950 and 1964 were studied, all having been first seen before the age of 1 year. In retrospect, the year 1957 seemed to be a watershed in the treatment of this series of patients, and they were therefore divided into 2 groups. Group A, 30 patients seen before 1957; Group B, 46 patients seen after 1957. The clinical, radiological, and bacteriological findings in the 2 groups at entry were similar as to age of incidence, severity of the initial respiratory symptoms, abnormalities on chest radiographs, and bacteriology of the cultures of cough swabs. Treatment of Group B patients was generally more vigorous, with antibiotics used more efficiently to treat pulmonary infection. When the patients were followed up and their pulmonary status was assessed clinically and radiologically, at 1 year and at 5 years of age, Group B patients were found to be significantly less severely affected than Group A patients. It is concluded that vigorous treatment of cystic fibrosis can reduce mortality in infancy, and considerably improve the pulmonary status during childhood.
对1950年至1964年间诊治的76例囊性纤维化患者进行了研究，所有患者首次就诊时均未满1岁。回顾过去，1957年似乎是这组患者治疗的一个分水岭，因此将他们分为两组。A组30例，于1957年前就诊；B组46例，于1957年后就诊。两组患者入院时的临床、放射学和细菌学检查结果在发病年龄、初始呼吸道症状严重程度、胸部X光片异常情况以及咳嗽拭子培养的细菌学方面相似。B组患者的治疗通常更为积极，使用抗生素治疗肺部感染的效率更高。当对患者进行随访并在1岁和5岁时对其肺部状况进行临床和放射学评估时，发现B组患者的病情严重程度明显低于A组患者。得出的结论是，积极治疗囊性纤维化可降低婴儿期死亡率，并显著改善儿童期的肺部状况。
