免疫化疗对胃肠道癌患者淋巴细胞反应的影响。
Effect of immunochemotherapy on lymphocyte response of patients with gastrointestinal cancer.
作者信息
Mashiba H, Yoshinaga H, Matsunaga K, Gojobori M, Furusawa M
出版信息
J Surg Oncol. 1979;12(3):275-9. doi: 10.1002/jso.2930120312.
Patients with gastrointestinal cancer were treated with 5-fluorouracil (5-FU) in combination with a streptococcal preparation, OK-432, or without OK-432 before operation, and lymphocyte response to PHA was examined. Oral administration of 5-FU with or without intramuscular injection of OK-432 did not affect the response. However, treatment with cytostatic drugs in combination with OK-432 markedly augmented the lymphocyte response to PHA, but the cytotoxic activity of lymphocytes was not elevated.
胃肠道癌患者在术前接受5-氟尿嘧啶（5-FU）联合链球体制剂OK-432治疗，或仅接受5-FU治疗，未联合OK-432，然后检测淋巴细胞对PHA的反应。口服5-FU无论是否联合肌肉注射OK-432均不影响该反应。然而，细胞抑制药物与OK-432联合治疗显著增强了淋巴细胞对PHA的反应，但淋巴细胞的细胞毒性活性并未升高。
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