Schwartz A, Rosenberg G, Spencer A, Barbeau A, Mars H, Libman I
Can Med Assoc J. 1972 Nov 18;107(10):973-6.
Eighty-eight patients with Parkinson's disease were treated with levodopa. A group of elderly patients 65 years and older was compared with a second group under the age of 65, and it was found that generally the younger patients could be treated with greater success than the older ones. Most of the elderly could not tolerate the large doses required to produce optimal physical recovery. Severity of complications forced discontinuance of treatment in a larger percentage of elderly patients. The rate of complications was about equal in the two groups, except the incidence of confusion, which was significantly higher in the elderly. Of the two deaths that occurred, both were in the older group. Results of treatment were better in patients whose families gave positive support.
88名帕金森病患者接受了左旋多巴治疗。将一组65岁及以上的老年患者与另一组65岁以下的患者进行比较，发现一般来说，年轻患者的治疗成功率高于老年患者。大多数老年人无法耐受实现最佳身体恢复所需的大剂量药物。并发症的严重程度迫使更大比例的老年患者停止治疗。两组的并发症发生率大致相同，但意识模糊的发生率在老年人中明显更高。在发生的两例死亡病例中，均在老年组。家庭给予积极支持的患者治疗效果更好。
